Translating genomics into risk prediction
نویسندگان
چکیده
منابع مشابه
Translating genomics into improved healthcare
Since the work of Mendel, genetic research has been punc‐ tuated by key, shifting advances (box 1), which culminated in the first draft sequence of the human genome in 2001. Although most of the human genome sequence is shared by everyone, a small proportion varies between individuals. This variation, acting together with environmental factors, is thought to underlie differences in physiology, ...
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Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis f...
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The medical directors of the organ-procurement organizations can determine the ABO compatibility of the exchange pairs and the proximity of their centers and note the date of the listings. Equipoise should be achieved in terms of the medical characteristics of the donors and recipients; therefore, donors and recipients should be aware of the medical characteristics of their exchange partners, e...
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With the rapidly developing use of next-generation sequencing technologies, there has been a surge in our knowledge of the genomic landscape of prostate cancer and a movement toward developing a molecular subclassification system for the disease. With this new understanding comes great clinical potential, both for the development of biomarkers as well as new therapeutic targets. Herein, we high...
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BACKGROUND A recent large-scale, chemical screening study raised the hypothesis that propranolol may increase the risk of myopathy. We tested this hypothesis in a large population to assess whether (1) propranolol use is associated with an increased risk of myopathy and (2) the concurrent use of propranolol with a statin may further increase risk of myopathy. METHODS New users of propranolol ...
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ژورنال
عنوان ژورنال: Thorax
سال: 2017
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2016-209934